Canada Goose Outlet Treating spinal cord Canada Goose Jackets injuries with a dual action drug Canada Goose Outlet
canada goose black friday sale Injuries to the spinal cord are devastating. They can cause severe motor deficits along with heart canada goose jackets sale and breathing canada goose problems. To make matters canada goose clearance worse, there are currently no treatments known that can fix damage to the spinal cord. It is difficult for the body to recover after these injuries because scar tissue prevents the growth of severed axons. It is vital for the damaged nerves to grow back and make connections in order for the body to heal. uk canada goose outlet In response to injury, connective tissue cells named fibroblasts migrate to the site, create canada goose coats on sale the scar, and produce inhibitory cheap canada goose uk signals that stop the axons from growing. If we wanted to design a drug to improve recovery, it should stop fibroblasts from forming the scar and help axons grow. buy canada goose jacket Most importantly, and this is no small task, the drug must be able to get to the spinal cord canada goose black friday sale
buy canada goose jacket The brain and spinal cord are parts of the central nervous system Canada Goose online and they are bathed in a solution called cerebrospinal fluid (CSF). The central nervous system and the surrounding CSF is obviously a vital part of the body; thus, it is protected by the blood brain barrier. This barrier protects the central nervous system and is very selective in the molecules it lets pass. It is hard to find drugs that can cross the blood canada goose factory sale brain barrier, let alone have positive effects. There are chemicals out there that allow for nerve growth, but canada goose black friday sale scientists from Germany have recently found a small molecule that not only supports axon growth through injured areas, but can cross the blood brain barrier. buy canada goose jacket
canada goose coats on sale The drug epothilone uk canada goose B (epoB) stabilizes microtubules, proteins in the cell that help make its shape and grow. The fascinating part is that epoB affects axons and fibroblasts differently. In axons, it promotes the polarization of microtubules, meaning they accumulate at one end of the cell and promote growth. With epoB added, the microtubules form at the tips of the cut axons and elongate them. Axons in culture, labeled in the picture above in white, exposed to epoB can even grow in the presence of inhibitory growth signals, usually secreted by fibroblasts. In fibroblasts, however, epoB halts cell growth and the polarization of microtubules. This prevents the migration of fibroblasts to the site of injury. In canada goose clearance sale the picture https://www.uscanadagooseoutletsale.com to canada goose uk black friday the Canada Goose Online right, fibroblasts are treated with epoB. After treatment, there are stable, detyrosinated microtubules (DetyrTub in green) all over the cell. Without a specific direction of microtubule growth, the cell can’t move. Without fibroblasts migrating to the injury, there is less scaring and inhibitory signaling. canada goose coats on sale
Canada Goose Parka The scientists showed the drastic difference in drug effects between the two cell types is caused by a protein that associates with microtubules called tau that’s found in axons but not fibroblasts. Tau colocalizes with microtubules and affects their dynamics by Canada Goose sale binding proteins that cause stabilization. canada goose uk shop To show tau was responsible for the different responses, cheap Canada Goose they removed tau Canada Goose Outlet from neurons and added tau to fibroblasts. When they removed tau from axons using shRNAs, the canada goose store axons no longer grew when exposed to epoB, and when they introduced tau into fibroblasts, they were able to migrate again. Canada Goose Parka
canada goose To show that this could work in a live organism, they used the drug on rats. The rats they studied had partial spinal cord lesions which caused motor movement difficulties. They then injected epoB or a control solution without the drug into canada goose uk outlet the rats. The rats injected canada goose coats with epoB saw significant increases in the length of axons at the injury, and improvements in their motor movements over the control rats. This is displayed in the graph below. It shows a reduction canadian goose jacket in mistakes while the rats walked cross a horizontal ladder, an indication their motor skills have improved. The axons in the spinal cord could also grow through the injured area. To the right, a picture of a rat spinal cord injury (outlined with the white dash line) has axons (in green with peaks labeled with white arrows) growing successfully only when treated with epoB. canada goose
canada goose coats Although it would be a reach to say that epoB is the panacea for future injuries, these results are groundbreaking and extremely promising. To turn this into a clinically relevant treatment, epoB would have to go through many clinical trials before it could be Canada Goose Coats On Sale used commercially. Before then, it is crucial that we see more dramatic results, look at side effects, and possibly test how it could be mixed Canada Goose Parka with other drugs. Seeing small improvements in motor tasks in rats is a far cry from helping people who have suffered from truamatic injuries. That being said, even if we buy canada goose jacket cheap may be years from a real treatment, this exciting study shows there may be hope, and, at the very least, some extremely interesting biology canada goose coats.